Scholarly Article
Ethanolic fruit extract of Zanthoxylum rhetsa mediates anti-cancer properties against Diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in mice
JESMIN SULTANA, ANKUR JYOTI DEKA, EYASIN ALI, ABDUL MALIK, SUHAIL AKHTAR, BARNALI DEKA, DIPANKAR BUJARBARUAH, SUBHASH MEDHI
1970-01-01 · Azerbaijan Pharmaceutical and Pharmacotherapy Journal · DOI: 10.61336/appj/24-03-53
Abstract
Hepatocellular Carcinoma is a fatal disease and the third biggest cause of mortality from cancer. Because chemotherapy treatment may have a variety of adverse effects, the use of alternative cancer therapies has been a prominent focus of study. When compared to other drug discovery sources, traditional medicine has given several unique therapeutic molecules for preventative and curative therapy. This study examined the hepatoprotective potential of an ethanol-based extract of Zanthoxylum rhetsa fruits against Swiss albino mice's Diethylnitrosamine (DEN)-induced liver cancer. The animals were given oral dosages of 100 and 250 mg/kg body weight of the ethanolic extract, whereas DEN was delivered intraperitoneally once a week for 21 days. At the end of the treatment period, the animals were sacrificed, and liver tissue as well as blood were obtained to determine marker enzymes and oxidative stress indicators. On estimate, the treated group showed an improvement in the marker and antioxidant activity. These findings showed that the increased enzyme levels revealed a protective mechanism for Z rhetsa fruit extract in DEN-induced HCC in mice. The biochemical parameters were corroborated by histological examination of the animals' livers. As a result, ethanol extracts of Z rhetsa fruits have substantial anticancer effects.
Keywords
Zanthoxylum rhetsa, HCC, DEN, SGPT, SGOT, ALP, GSH, SOD, GST, CAT, GPx
Citation Details
Azerbaijan Pharmaceutical and Pharmacotherapy Journal