Scholarly Article
Evaluation of the Antibacterial Activity of Cucurbita maxima Seed Oil Against Multidrug-Resistant Foodborne Pathogens
Esra Elmaghbub, Halima Nashnush, Rabya Lahmer
2025-10-14 · AlQalam Journal of Medical and Applied Sciences · University of Tripoli Alahlia
Abstract
This study aimed to investigate the antibacterial activity of cold-pressed pumpkin seed oil (Cucurbita maxima) against selected foodborne multidrug-resistant (MDR) pathogens. The oil's inhibitory effect was evaluated against Klebsiella pneumoina, Salmonella enterica, Bacillus cereus, and Staphylococcus aureus using the agar well diffusion method. Seven concentrations (5%-100%) were tested with amoxicillin as the positive control and dimethyl sulphoxide (DMSO) 5% as the negative control. The results demonstrated that pumpkin seed oil exhibited a concentration-dependent antibacterial activity. Significant inhibition was observed even at low concentrations (5%), with significant differences between the different concentrations (p<0.05). These findings suggest that Cucurbita maxima seed oil promises to be a natural antibacterial agent and could serve as an alternative for managing MDR foodborne infections.
Keywords
Cucurbita maxima Seed Oil, Antibacterial Activity, Multidrug-Resistant Bacteria, Foodborne Pathogens, Libya
Citation Details
AlQalam Journal of Medical and Applied Sciences, Vol. 8, No. 4, pp. 2250-2254