Scholarly Article
Effect of Sub- Chronic Administration of Omeprazole on Hematological and Biochemical Parameters in Fischer Male Rats
Samia Elkedrawy, Alaa Aldouayb, Akraam Areebi, Abdalmohymen Shuqman, Bushra Aboukhadeer
2024-12-09 · AlQalam Journal of Medical and Applied Sciences · University of Tripoli Alahlia
Abstract
Long-term use of proton pump inhibitors (PPIs) is believed to have various potential adverse events. Omeprazole is a part of PPIs most commonly prescribed worldwide; it irreversibly binds to the H+-K+ ATPase enzyme system in the gastric parietal cells to reduce the secretion of H+ ions into the lumen of the stomach. The main objective of the current work is to assess the adverse effects of omeprazole medication on certain hematological and biochemical parameters in rats who were on treatment for three months. We conducted a comparative cross-sectional study between March 2024 and July 2024. 20 male Fischer rats (Albino) aged two months, weighting (200-250g) was obtained from the animal house located in the Libyan center for medical research, in the city of Alzawia, and were enrolled in this study. Rats were divided into two groups, the first group was the control (Normal saline group) (n=10), second was administered 40mg/kg omeprazole via IP route (n=10) once daily. Complete blood count and biochemical parameters were measured for both groups. The treatment group had remarkably significant reductions in the number of red blood cells (RBCs) (p 0.05). Blood urea levels (p 0.05). ارتفعت مستويات اليوريا في الدم (p<0.001) بشكل ملحوظ في مجموعة العلاج التي عولجت بدواء أوميبرازول. أظهرت النتائج أيضًا أن مجموعة العلاج شهدت انخفاضًا كبيرًا في مستويات الكالسيوم (p<0.001) مقارنة بمجموعة التحكم. قد يؤدي الاستخدام المطول لأوميبرازول إلى آثار ضارة على الملف الدموي، وخاصة خلايا الدم الحمراء ومؤشراتها مما يؤدي إلى تطور فقر الدم لدى المرضى الذين يتناولون هذا الدواء. علاوة على ذلك، قد يؤدي ذلك إلى اضطرابات في الملف الكيميائي الحيوي ومستويات المعادن والفيتامينات نتيجة لتأثر الامتصاص
Citation Details
AlQalam Journal of Medical and Applied Sciences, Vol. 7, No. 4, pp. 1511-1517