Scholarly Article
Anti-Ulcerogenic and Toxicological Evaluation of Polyphenol Rich Extract of Cochlospermum Planchonii Roots in Tissues of Aspirin-Induced Ulcerogenic Rats
Rukayat A. Oyegoke, Mikhail O. Nafiu
2024-04-25 · AlQalam Journal of Medical and Applied Sciences · University of Tripoli Alahlia
Abstract
The folkloric use of Cochlospermum planchonii roots as an anti-ulcerogenic and its safety is yet to be affirmed with scientific confirmation and this study is designed to do that. This study evaluated the anti-ulcerogenic activity and safety of polyphenol rich extract of Cochlospermum planchonii (PRECPR) roots in aspirin-induced ulcerogenic rats. These roots were processed to give dosages of 50, 100 and 150 mg/kg bodyweight. Thirty rats (138.0 ± 5.0 g) were assigned into six groups. Rats in group A (control) received 1.0 ml of distilled water. Those in groups B - F were administered 200 mg/kg body weight of aspirin and then treated with 1.0 ml of distilled water, 1.0 ml equivalent to 0.05 mg/kg body weight of omeprazole, 50, 100 and 150 mg/kg body weight of PRECPR, respectively. PRECPR dose-dependently increased (p > 0.05) nitric oxide, pH, activities of enzymes, concentrations of bilirubin, creatinine, haematological indices and decreased pepsinogen, volume and acidity of the gastric juice significantly. These results compared favourably (p 0.05) أكسيد النيتريك، ودرجة الحموضة، وأنشطة الإنزيمات، وتركيزات البيليروبين، والكرياتينين، ومؤشرات الدم، وانخفاض البيبسينوجين، وحجم وحموضة عصير المعدة بشكل ملحوظ. تمت مقارنة هذه النتائج بشكل إيجابي (P <0.05) مع تلك الخاصة بالمجموعة المعالجة بالأوميبرازول. قدمت هذه الدراسة إشارة قوية إلى أن هذا المستخلص يمكن أن يكون بمثابة عامل مضاد للقرحة وهو آمن.
Citation Details
AlQalam Journal of Medical and Applied Sciences, Vol. 7, No. 2, pp. 278-287