Scholarly Article
Clinical and Biochemical Profile of Libyan Patients with Serology and Biopsy Proven Celiac Disease
Samira Alkuni, Fatima Elhawil, Salma Sanok, Rabea Markus, Mohamed Frandah
2022-05-19 · AlQalam Journal of Medical and Applied Sciences · University of Tripoli Alahlia
Abstract
Background and aims. Celiac disease is a long-term immune disorder that primarily affects the small intestine. Iron deficiency anemia is the most widely experienced anemia in humans, which is a common extra intestinal manifestation of celiac disease. The aim of the current study is to describe the clinical and biochemical profile of adult Libyan celiac disease patients. Method. This was a case series study conducted by reviewing the medical records of the 100 patients diagnosed as celiac disease and followed in gastro-enterology clinic in Tripoli university hospital during the study period. A relevant data obtained from the records in a preformed case sheet. Result. The total number of celiac disease patients was 100 patients. Of them, 88 patients were females (88%) and 12 patients were males (12%). Patient age during the study were from 15 years to 45 years. Total villous atrophy (type3 lesion) was the commonest histopathological finding (62%) and subtotal villous atrophy in (38%) and none had T-Cell Lymphoma. About 9% of patients were asymptomatic and 91% symptomatic. Gastrointestinal symptoms (diarrhea in 60%, weight loss in 24%, and 17% of patients with abdominal distension), non- gastrointestinal symptoms like skin disorders (dermatitis herpetiformis) were diagnosed in 4 patients 4%. While, neuropsychiatric disorder (depression) was seen in 1 patient 1%, osteopenia in 2 patients 2% (low vitamin D and low serum Ca+2 and Mg+2), 5% of patients had raised AST and ALT, and prolonged PT in 3%. Conclusion. There was significant correlation between female patients having iron deficiency anemia and/or diarrhea to be celiac disease. Female patients present with iron deficiency anemia and / or diarrhea should be routinely screened for celiac disease by serological tests and then confirmed by endoscopic small bowel biopsies.
Keywords
Clinical, Biochemical, Serology, Biopsy, Celiac Disease
Citation Details
AlQalam Journal of Medical and Applied Sciences, Vol. 5, No. 1, pp. 263-266