Scholarly Article
Screening for Analgesic and Anti-Inflammatory Effect of Antioxidants by Applying Formalin Test Using Albino Mice
Aburawi S*, Al Tubuly R, Friwan A, Al-Ghdamsi M
2017-07-08 · AlQalam Journal of Medical and Applied Sciences · University of Tripoli Alahlia
Abstract
Objective: Aim of this work is to evaluate analgesic and anti-inflammatory effects of antioxidants. Methods: Formalin test was applied using albino mice. This model constitutes two distinct phases: the first phase represents the irritating effect of formalin at the sensorial fiber-C, while the second phase is inflammatory pain response. Results: Vitamin C, vitamin E and selenium have analgesic effect for neuropathic pain. Vitamin E and selenium produce anti-inflammatory effect.Conclusion: Analgesic effect for neuropathic pain was observed with vitamin C, vitamin E and selenium treatment. Anti-inflammatory effect is produced by vitamin E and selenium administration; while Vitamin C produces insignificant decrease in inflammation in the dose used.
Keywords
Antioxidant, Vitamin C, Vitamin E, Selenium, Formalin Test
Citation Details
AlQalam Journal of Medical and Applied Sciences, Vol. 1, No. 1, pp. 1-8